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Ritter reaction : ウィキペディア英語版 | Ritter reaction The Ritter reaction is a chemical reaction that transforms a nitrile into an ''N''-alkyl amide using various electrophilic alkylating reagents. The original reaction formed the alkylating agent using an alkene in the presence of a strong acid: Primary, secondary,〔Bishop, R.; In ''Comp. Org. Synth.''; Trost, B.M., Fleming, I.; Eds.; Pergamon Press: New York, 1992; Vol. 6, 261-300. (Review)〕 tertiary, and benzylic alcohols, as well as ''tert''-butyl acetate, also successfully react with nitriles in the presence of strong acids to form amides via the Ritter reaction. ==History== The Ritter reaction is named after John J. Ritter, an American chemist who received his Ph.D. from Columbia University. In 1948, P. Paul Minieri, Ritter's student, submitted work on the reaction as his Ph.D. thesis. The reaction still has significance today due to its applicability and reproducibility of amides via stabilized carbocations.〔
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